Andrews had a revival of her film career in 2000s in family films such as The Princess Diaries (2001), its sequel The Princess Diaries 2: Royal Engagement (2004), the Shrek animated films (2004–2010), and Despicable Me (2010). In 2003 Andrews revisited her first Broadway success, this time as a stage director, with a revival of The Boy Friend at the Bay Street Theatre, Sag Harbor, New York (and later at the Goodspeed Opera House, in East Haddam, Connecticut in 2005).
Andrews is also an author of children's books, and in 2008 published an autobiography, Home: A Memoir of My Early Years.