Lane made his professional theatre debut in 1978 in an off-Broadway production of "A Midsummer Night's Dream". He gained widespread recognition for his roles in Broadway productions such as "A Funny Thing Happened on the Way to the Forum," "The Producers," and "Angels in America". His film credits include "The Lion King," "The Birdcage," "Mouse Hunt," and "The Producers".
In addition to his stage and film work, Lane has appeared in various television series, including "Modern Family," "The Good Wife," and "Only Murders in the Building". He has been married to Devlin Elliott since 2015.