In 2012, Wilson appeared in the films What to Expect When You're Expecting, Struck by Lightning, and Bachelorette, which led to Variety naming her one of their βTop Ten Comics to Watch for 2012β. She also played the role of Fat Amy in the musical comedy Pitch Perfect film series (2012β2017), which earned her several award nominations and wins, including the MTV Movie Award for Best Breakthrough Performance and a Teen Choice Award for Choice Movie Actress. In 2016, Wilson appeared in the films How to Be Single and Grimsby.
Wilson wrote and starred in Super Fun Night (2013), a television sitcom that aired for one season on ABC. In 2019, she starred in her first lead role as Natalie in Isn't It Romantic, and went on to play Penny Rust in The Hustle, Jennyanydots in Cats, and Fraulein Rahm in Jojo Rabbit.