As a lead actress in films, Hahn starred in Joey Soloway's comedy-drama Afternoon Delight (2013), the comedy film Bad Moms (2016) and its sequel A Bad Moms Christmas (2017), and Tamara Jenkins's drama Private Life (2018). She has appeared in various other dramatic films, including Revolutionary Road (2008), This Is Where I Leave You (2014), The Visit (2015), and Captain Fantastic (2016). She voiced Ericka Van Helsing in two films of the Hotel Transylvania franchise (2018–2022) and Doctor Octopus in Spider-Man: Into the Spider-Verse (2018).
In television, Hahn had guest roles on the NBC sitcom Parks and Recreation (2012–2015) and the Amazon Prime Video comedy-drama series Transparent (2014–2019). Hahn starred in the HBO miniseries Mrs. Fletcher (2019) and I Know This Much Is True (2020). She portrayed Agatha Harkness in the Disney+ miniseries WandaVision (2021) and its spin-off Agatha All Along (2024). For the former, she was nominated for a Primetime Emmy Award for Outstanding Supporting Actress. For starring in the Hulu series Tiny Beautiful Things (2023), she received a nomination for a Primetime Emmy Award for Outstanding Lead Actress.
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