Emmanuel gained wider recognition for her role as Missandei in the HBO fantasy series Game of Thrones (2013–2019). He continued her career with supporting roles in Maze Runner: The Scorch Trials (2015) and its sequel Maze Runner: The Death Cure (2018), the Fast & Furious films Furious 7 (2015), The Fate of the Furious (2017), F9 (2021), and Fast X (2023). She has since taken on lead roles in Army of Thieves (2021) and Megalopolis (2024).
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