She starred in numerous commercially successful films throughout the 1990s, including the romantic comedies My Best Friend's Wedding (1997), Notting Hill (1999) and Runaway Bride (1999). She won the Academy Award for Best Actress for playing the title role in the biographical drama Erin Brockovich (2000). Roberts achieved further film success in the following decades with Ocean's Eleven (2001), Ocean's Twelve (2004), Charlie Wilson's War (2007), Valentine's Day (2010), Eat Pray Love (2010), August: Osage County (2013), Wonder (2017), Ticket to Paradise (2022), and Leave the World Behind (2023). Roberts also received a Primetime Emmy Award nomination for the HBO television film The Normal Heart (2014), had her first regular television role in the first season of the Amazon Prime Video psychological thriller series Homecoming (2018), and portrayed Martha Mitchell in the Starz political limited series Gaslit (2022).
In addition to acting, Roberts runs the production company Red Om Films, through which she has served as an executive producer for various projects she has starred in and the first four films of the American Girl franchise (2004–2008). She has acted as the global ambassador for Lancôme since 2009. She was the world's highest-paid actress throughout the majority of the 1990s and the first half of the 2000s. She received a then-unprecedented fee of $20 million and $25 million for her roles in Erin Brockovich (2000) and Mona Lisa Smile (2003), respectively. As of 2020, Roberts's net worth was estimated to be $250 million. People magazine has named her the most beautiful woman in the world a record five times.